BioTechniques - Turn Any Gene On or Off

Source: Cell

CRISPR marches along:

"Since the completion of the Human Genome Project, a primary goal for the research community has been to determine the function of individual genes and their interactions with each other in cellular pathways. Established approaches for functional gene analysis such as RNAi and ORF overexpression often fail to produce a phenotype and may result in off-target effects. Now, a team of researchers at the University of California, San Francisco has developed a variation of the CRISPR/Cas9 system to activate or repress transcription of genes...."  @ BioTechniques - Turn Any Gene On or Off:

Reference
Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. “Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation” Cell 159. 647-661, 2014. doi: 10.1016/j.cell.2014.09.029.