Abstract
SARS-CoV-2 vaccines are highly effective at preventing
COVID-19-related morbidity and mortality. As no vaccine is 100% effective,
breakthrough infections are expected to occur. We analyzed the virological characteristics
of 161 vaccine breakthrough infections in a population of 24,706 vaccinated
healthcare workers (HCWs), using RT-PCR and virus culture. The delta variant
(B.1.617.2) was identified in the majority of cases. Despite similar Ct-values,
we demonstrate lower probability of infectious virus detection in respiratory
samples of vaccinated HCWs with breakthrough infections compared to
unvaccinated HCWs with primary SARS-CoV-2 infections. Nevertheless, infectious
virus was found in 68.6% of breakthrough infections and Ct-values decreased
throughout the first 3 days of illness. We conclude that rare vaccine
breakthrough infections occur, but infectious virus shedding is reduced in
these cases.
Virological characteristics of SARS-CoV-2 vaccine
breakthrough infections in health care workers
Marc Conrad Shamier, Alma Tostmann, Susanne Bogers, Janet De
Wilde, Jeroen IJpelaar, Willemijn Van Der Kleij, Herbert De Jager, Bart
Haagmans, Richard Molenkamp, Bas Oude Munnink, Carsten van Rossum, Janette
Rahamat-Langendoen, Nannet Van Der Geest, Chantal Bleeker-Rovers, Heiman
Wertheim, Marion Koopmans, Corine GeurtsvanKessel
medRxiv 2021.08.20.21262158; doi:
https://doi.org/10.1101/2021.08.20.21262158
Thanks Chise.
Chise also mentions this study:
Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK
Koen B. Pouwels Emma
Pritchard, Philippa C. Matthews, Nicole Stoesser, David W.
Eyre, Karina-Doris Vihta, Thomas House, Jodie Hay, John I
Bell, John N Newton, Jeremy Farrar, Derrick Crook, Duncan
Cook, Emma Rourke, Ruth Studley, Tim Peto Ian Diamond, A. Sarah
Walker and the COVID-19 Infection Survey Team
See also: Collected COVID-19 risk yardsticks
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