The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high incidence of mammary tumors in the females. The largest number of rat tumors occurred in the endocrine system, mainly the pituitary and adrenal glands, with females exhibiting a higher incidence than males. There were no liver tumors.
The largest group of mouse tumors occurred in the pulmonary system, with a higher incidence in females than in males. Urinary system tumors were observed in the males but not in the females. Tumors of the integument, reproductive organs, and the reticuloendothelial and lymphatic organs were also observed.
Cancer Research 1973
Update
Spontaneous endocrine tumors in Sprague-Dawley rats.
Suzuki H, Mohr U, Kimmerle G.
Abstract
Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.
J Cancer Res Clin Oncol. 1979 Oct;95(2):187-96.
Incidences of Selected Lesions in Control Female Harlan Sprague–Dawley Rats from Two-Year Studies Performed by the National Toxicology Program
Amy E. Brix, Abraham Nyska, Joseph K. Haseman, Donald M. Sells, Micheal P. Jokinen and Nigel J. Walker
2 year old rats get tumours and bad kidneys:
Table 1
Incidences of lesions observed in vehicle control female Harlan Sprague-Dawley core study rats
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